75K Miles From American Airlines
There’s currently a very hot deal going on where you can get 75K miles for signing up for an American Airlines credit card. There are three versions of the card floating around (Visa, Visa Business, Amex) so it’s possible to rack up 225K miles if you are approved for all three.
Only condition is you have to spend $1,500 within the first 6 months, which should be pretty easy to do. The first year fee is waived and you can always cancel after you receive the miles if you don’t want to keep the card.
FlyerTalk has a very extensive thread on it with links to the offer.
75K miles is a ton and will get you pretty far, see this AA rewards chart.
Also, read my old post regarding earning free flights through credit card miles.